Thursday, August 27, 2020
Disclosure to Debacle Essay Presentation: The outgrowth of the monoclonal antibodies as regulative T cell activators raised an extraordinary passion among research laborers to create them as strong go-betweens for immunotherapy. Albeit huge numbers of these monoclonal antibodies have been advertised for the intercession of grouped illnesses [ 1 ] ( Bhogal, 2007 ) , some of them couldn't make this completion because of their discontinuance in the clinical stages. One such model hypothetical record is TGN1412. TGN1412 is an IgG4 sort of monoclonal immunizer which goes about as superagonist for CD28, a co-stimulatory receptor required for T-cell initiation. Since TGN1412 initiates the T cell without foremost enactment of the T cell antigen ( TCR ) receptor it was assigned as a superagonist [ 2 ] ( Bhogal, 2006 ) . In any case, the vision of utilizing TGN1412 as a calming specialist was slammed when it flopped in the main proportion of the clinical surveies. The stage 1 clinical trial of this promising medication r ose to be a calamity taking to hazardous impacts in the voluntaries. This reappraisal centers around the find, presymptomatic turn of events and moral concerns identified with the medication and the potential missteps made during the period from its find to the ruin. All the above elements had a falling result and contributed enormously to the medication s disappointment. This disaster of TGN1412 requests the significant change in the current medication testing structure for the progression of the great beyond improvement of medications. Improvement: - To advance the initiation of immunosuppressive regulative T-cells, TeGenero, a German Pharmaceutical organization created TGN1412, an entirely adapted monoclonal immunizer by protein innovation of the non-human species produced counter acting agent ( mice neutralizer ) to acquire belongingss explicit to universes. Protein innovation included the transportation of the correlative deciding pieces of a mouse hostile to human CD28 ( 5.11.A1 ) immunizer into human counter acting agent link proteins got from Chinese hamster ovary ( CHO ) cells [ 1 ] ( Bhogal, 2007 ) . Autoreactive T-cells doing redness and autoimmunity against specific cells and natural structure tissues are kept in immutable check by regulative T cells. Typical T cell actuation requires both the T cell receptor and CD28, a receptor protein on surface of T cells for its multiplication and initiation [ 3 ] ( Vitetta, 2006 ) . Orchestrating to surveies directed by TeGenero, TGN1412 can trip the T cells everyth ing being equal and discharge cytokines by pointing an antigenic determinant of CD28, an amazingly rationed piece of CD cringle which is uncovered on the extracellular surface of T-cell films, along these lines shortcircuiting the interest to T cell receptor particularity. With this expectation of stamp bringing down the safe framework by enactment of regulative T cells, TGN1412 was created as a new treatment for immune system and provocative illnesses. In Rheumatoid Arthritis, an immune system ailment, TGN1412 decreased the degrees of fiery go-betweens by enactment of the T-cells. B-CLL, most basic sort of incessant leukemia is related with a high white platelet tally and moderate growth of a particular kind of B-cell. TGN1412 is efficacious in intercession of B-CLL by non simply triping and energizing the developing of lymph cells however next to elevating the antigen demonstrating capacity of B-cells related with the B-CLL. [ 2 ] ( Bhogal, 2006 ) We will compose a custom exposition test on Discovery to Debacle explicitly for you for just $16.38 $13.9/page Request now We will compose a custom paper test on Discovery to Debacle explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer We will compose a custom article test on Discovery to Debacle explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer After complete turn of events, pre-clinical and bodily testing, TeGenero chose to proceed with first in human clinical test to gauge the wellbeing, decency and pharmacokinetics of TGN1412 and administer its immunogenicity and consequences for T cells, B cells and on cytokine degrees in blood serum. For this plan TeGenero enrolled Parexel, a different clinical test unit. The test convention put together by Parexel was approved by Medical wellbeing regulative department ( MHRA ) on 27th January 2006 endorsed by Medical Ethics commission on fourteenth February 2006. [ 2 ] ( Bhogal, 2006 ) Stage 1 Clinical test disappointment: Harmonizing to the test convention structured, on 13 March 2006, the main gathering of 6 voluntaries got a measurements of 0.1mg/kg on and was booked to have farther raising portions more than three-week time span. Be that as it may, the test turned ruinous and must be suspended when these voluntaries created cytokine discharge disorder with an unmanageable expansion in tissue cytokine fixations at long last taking to different organ disappointment. [ 4 ] ( Schraven, 2008 ) Preclinical: The test directed by MHRA and the European governments after the clinical test expressed that there were no mix-ups in manufacture, readiness and no signs of corrupt in the group TGN1412 regulated to the voluntaries [ 4 ] ( Schraven,2008 ) . To thwart such lethal occasions in future, the master bunches were enrolled by Secretary of the region for wellbeing to investigate the missteps taking to disappointment of the test. The presymptomatic surveies with respect to the species decision, invitro and exvivo testing, fitting portion decision and animalistic surveies were focuses exposed to reconsideration. In-vitro testing: Sing the species decision, non human Primatess are most as often as possible considered for the presymptomatic testing because of their nearby familial and pharmacological similitude to universes. In occurrence of TGN1412, Rhesus macaques and the cynomolgus monkeys were utilized as the hypothetical record for surveies on the balance that the 6 amino corrosive epitope on the C D circle of CD28 to which the medication seems to follow is entirely comparable and rationed in both the macaques and the universes. [ 5 ] ( Stebbings, 2009 ) After cautious planning of the TGN1412 dependent on the monitored arrangement of the non-human Primatess, it could put the recombinant human cells indicating CD28 with high following fondness. Particularity of TGN1412 for CD28 was affirmed with following surveies on the human cells indicating CD-28, Cytotoxic T lymphocyte antigen-4 ( CTLA-4 ) and the inducible co-trigger ( ICOS ) , in which TGN1412 did non uncover cross-reactivity with the CTLA-4 and ICOS with the way that both these proteins have high evaluation of amino-corrosive arrangement homology with CD28. So as to assist synergize the species selectivity, following capacity of TGN1412 in the human, Macaca mulatta and cynomolgus monkeys and gnawers and marmoset T-cells was assessed. It was discovered that nanomolar grouping of TGN1412 could cling explicitly to human and Macaca mulatta and cynomolgus monkeys yet non with marmoset and rat T-Cells because of distinction in the antigenic determinant of the marmoset and human CD28. In marmoset species, 2 of the amino acids out of 6 contrast when contrasted with rodent in which every one of the 6 amino acids are unique, thusly affecting the official of the TGN1412 to CD28 of these species. All these surveies incited the examination laborers to proceed with the surveies on the Macaca mulatta and cynomolgus macaques. [ 1 ] [ 2 ] ( Bhogal, 2006, 2007 ) Alongside pre-prevailing look in human lien, CD28 is other than communicated in the lymphatic, respiratory, connective and female generative tissues. Despite the fact that being insightful of this reality, the cross-reactivity surveies in cynomolgus monkeys were performed with constrained tissues non representing total tissue circulation of TGN1412. In add-on to this, cross-reactivity was seen with the respiratory CD28 which was unexplained in the divert assessment of presymptomatic preliminaries since respiratory disfunction was seen in the voluntaries who took part in the test. [ 2 ] ( Bhogal, 2006 ) . In this way it was proposed that executing such surveies with more extensive collection of tissues would extraordinarily aid the great beyond advancement of immunobiologics. In add-on to authoritative and the cross responsiveness surveies, invitro preliminaries with human fringe blood mononuclear cells ( PBMC ) were performed for foreseeing the invivo explicitness and the species affectability for TGN1412 [ 5 ] ( Stebbings, 2009 ) . Since most maps of the antibodies are intervened by following of their Fc part to Fc receptor fusing cells [ 4 ] ( Schraven,2008 ) , in-vitro preliminaries discovering particularity, with Fc immobilized TGN1412, which mirrored the Fc restricting were acted in cynomolgus monkeys and grown-up male, because of high evaluation of likeness in their grouping homology of the Fc receptor. It showed that TGN1412 could stir the reaction only when it was immobilized onto a surface, or coupled by means of immobilized Fc-explicit counter acting agent. As opposed to the above outcomes, immobilization of TGN1412 in the cynomolgus monkeys did non demo its activity as a superagonist [ 5 ] ( Stebbings, 2009 ) . On the other hand it goes about as customary CD28 agonist requiring T-cell receptor and CD28 enactment for T cell incitement or more all that it did non trip the cytokine creation as found in the voluntaries in the clinical tests [ 2 ] ( Bhogal, 2006 ) . Every one of these outcomes demonstrated hapless species decision for the presymptomatic preliminaries. Creature Trials: Pharmacokinetic and toxicological issues have been thought about in correspondence with animalistic surveies. Pharmacokinetic evaluations made during the relative overview of the TGN1412 with its variation TGN1112 in Macaca mulatta macaques, demonstrated that after their IV removal, both the medications were available in the blood serum for 20 yearss, with the pinnacle centralization of the T-cells and no indicant of the expanded cytokine degrees. Because of the overestimate of these impacts in invitro surveies, 28 twenty-four hours surveies were acted in the cynomolgus monkeys. The half existence of TGN1412 in these surveies was seen as 8 yearss with a
Saturday, August 22, 2020
Ptolemy XV Philopator Philometor Caesar (June 23, 47 BC Ã¢â¬ August 23, 30 BC), better known by the monikers Caesarion and Ptolemy Caesar, was the last lord of the Ptolemaic tradition of Egypt, who ruled mutually with his mom Cleopatra VII of Egypt, he was ostensibly the sole pharaoh. Caesarion was broadcasted a divine being, child of god and King of Kings. Caesarion, who was supposed to be Cleopatras child by Julius Caesar, was sent by his mom, with much fortune, into India, by method of Ethiopia.However, Caesarions watchmen, including his guide, either were themselves attracted by bogus guarantees of leniency into restoring the kid to Alexandria or maybe even sold out him; on the ground that Octavian welcomed him to take the realm of Egypt. The last clash between Mark Antony (Marcus Antonius) and Octavian (future Emperor Augustus), Antony shared control of the Republic in a triumvirate with Octavian and Lepidus, however Lepidus was constrained into retirement by Octavian in 36 BC, leaving Antony and Octavian as opponents. We will compose a custom article test on Jesus or Caesarion or on the other hand any comparative point explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page After two years, in 34 BC, Antony allowed different eastern terrains and titles to Caesarion and to his own three kids with Cleopatra. In the wake of losing the Battle of Actium to Octavians powers, Antony ended it all. Cleopatra took action accordingly, as indicated by custom executing herself by methods for a snake nibble on August 12, 30 BC. She was quickly outlasted by Caesarion, who was proclaimed pharaoh by his supporters, however he was before long murdered on Octavians orders, who might turn into the Roman sovereign Augustus.Had Caesarion executed in Alexandria, following the exhortation of Arius Didymus, he prompted Augustus to execute Caesarion, with the words ouk agathon polukaisarie (its not great to have an excessive number of Caesars) Augustus (Octavian) (September 23, 63 BC Ã¢â¬ August 19, 14 AD) is the author of the Roman Empire and its first Emperor, administering from 27 BC until his passing in 14 AD. Augustus passed on in 14 AD at 75 years old. He may have kicked the bucket from common causes, however there were unsubstantiated bits of gossip that his significant other Livia harmed him. He was prevailing as Emperor by his embraced child (likewise stepson and previous child in-law) Tiberius. Alexander Helios (25 December 40 BC conceivably between 29 BC 25 BC) was a Ptolemaic ruler and was the oldest child of Greek Ptolemaic sovereign Cleopatra VII of Egypt and Roman triumvir Mark Antony. Cleopatra Selene II (25 December 40 BC-somewhere in the range of 9 March 5 BC to 6), otherwise called Cleopatra VIII of Egypt or Cleopatra VIII was a Ptolemaic Princess and was the main little girl to Greek Ptolemaic sovereign Cleopatra VII of Egypt and Roman triumvir Mark Antony.Ptolemy Philadelphus ( August/September 36 BC Ã¢â¬ 29 BC) was a Ptolemaic ruler and was the most youthful and fourth offspring of Greek Ptolemaic Queen Cleopatra VII of Egypt, and her third with Roman Triumvir Mark Antony. Octavian took him and senior kin Alexander Helios and Cleopatra Selene II from Egypt to Italy. Octavian praised his military triumph in Rome, by strutting the three vagrants in substantia l brilliant chains in the roads of Rome. The chains were so overwhelming they couldn't walk, provoking responses of compassion from the Romans. The three kin were taken by Octavian and given to Octavia Minor, OctavianÃ¢â¬â¢s second senior sister and the kin father Mark Antonys previous spouse. Tiberius (16 November 42 BC Ã¢â¬ 16 March 37 AD), was Roman Emperor from 14 AD to 37 AD. Pontius Pilatus, referred to in the English-talking world as Pontius Pilate, was the fifth Prefect of the Roman area of Judaea, from AD 26Ã¢â¬36. He is most popular as the adjudicator at Jesus preliminary and the man who approved the execution of Jesus. As official, he served under Emperor Tiberius.
Friday, August 21, 2020
Common Application Challenge Essay SamplesCommon application challenge essay samples usually include the author's experiences, observations, experiences, life challenges, various or personal motives, and arguments. In addition, the examples may also include examples of unique ideas.Common application challenge essay samples often require the student to discuss an issue or problem he or she is experiencing in his or her work and daily life. Sometimes, the essays may contain a variety of topics like political, legal, ethical, philosophical, or theological. Common application challenge essay samples are reviewed on a daily basis, which means students must prepare hard.Common application challenge essay samples often give examples of events and scenarios. These examples are either fictional or factual. Common application challenge essay samples are often presented in a manner that is humorous. The content should be interesting and not boring.Common application challenge essay samples can be quite difficult to comprehend. Therefore, the instructions of these essays vary according to the requirement. For example, while some are written for college level courses, others may be for AP or honors class.Students are now able to apply online and they don't need to set foot in the school but just submit the information. However, while the application process has become more convenient, there are still some areas where one should still adhere to certain rules and guidelines. These include submissions of school grades, personal and work background information, and financial applications.Common application challenge essay samples can sometimes include a lot of unnecessary information. For example, the application essay may require a student to mention what position he or she is applying for, if he or she has any prior experience in that position, the GPA and AP/honors score, and what his or her work has been like. Some examples of the unnecessary information included in the es say are surveys, awards, or other paperwork.Common application challenge essay samples also include time-consuming processes. The essays must contain detailed descriptions of projects. This means the essay must show the relevance of the project to the student's career and achievements.Common application challenge essay samples can prove to be very confusing for students. Because of this, the guidance counselors can help the students understand what they are supposed to do with them. Furthermore, since these essays are already prepared, the guidance counselors can help the students focus their attention to the most important portions of the essay.
Monday, May 25, 2020
Romeo and Juliet. Macbeth. Hamlet. All of these plays have one thing in common. They were all written by a man named William Shakespeare. Now a household name, Shakespeare wrote a great number of plays and poems during the Elizabethan era. His work is studied by students everywhere, and his tales of adventure, comedy, and romance enjoyed by many. However, what if another author truly deserves the credit for his literature? Debated by historians for centuries, ShakespeareÃ¢â¬â¢s authorship has been challenged using a multitude of evidence. William Shakespeare was born in 1564 in Stratford-upon-Avon, England. Stratford was small, only being home to 1,500 inhabitants. Stratford was a market town where people from neighboring cities traveled to sell their crops, animals, and goods. ShakespeareÃ¢â¬â¢s birthday is unknown, but had to have taken place before his christening on April 26. As a child, he grew up in a well-off middle-class family. However, this all changed when the business of Williams father, John Shakespeare, began to falter in 1576. The Shakespeare family tumbled into debt. WilliamÃ¢â¬â¢s parents could not afford to send their son to work, so he was provided with free education at the local grammar school. The main purpose of the school was to teach its students Latin. Not much is known about Shakespeare between the time he was 15 until the year he became an up-and coming playwright in 1592. This period has been nicknamed Shakespeares lost years. What historians do know isShow MoreRelatedBiography of Will iam Shakespeare1709 Words Ã |Ã 7 PagesWilliam Shakespeare: Real or Fake? Introduction Who is the real Shakespeare? There are those who insist that William Shakespeare is the author of the many works attributed to him and reports state that there are those who believe some type of conspiracy exists to protect the real name of the author of those works. Claims state that there is no evidence to document William Shakespeare of Stratford as the author and that he did not have the aristocratic background, education, or knowledge to haveRead MoreWilliam Shakespeare Biography Essay1691 Words Ã |Ã 7 Pageswas Shakespeare Biography? Who was William Shakespeare? Where was he born? Where did he go to school? How did William Shakespeare live his life from the beginning to the ending? William ShakespeareÃ¢â¬â¢s life became a great mystery with lack of evidence to support any findings. His schooling, his family and parents will be revealed in my paper. Who were William ShakespeareÃ¢â¬â¢s parents? The parents of Mr. Shakespeare were John Shakespeare and Mary Arden Shakespeare. Mary Arden married William ShakespeareRead MoreEssay on Biography of William Shakespeare2736 Words Ã |Ã 11 PagesBiography of William Shakespeare William Shakespeare was born on April 23, 1564. He was baptized on April 24, 1564, in Stratford-upon-Avon, Warwickshire. He was the third of eight children born to John Shakespeare and Mary Arden, three of whom died in childhood. John was a well-known merchant and Mary was the daughter of a Roman Catholic member of the gentry, or high social position. The house where Shakespeare spent his childhood stood adjacent to he wool shop in which his father plied a successfulRead MoreWilliam Shakespeare: A Brief Biography651 Words Ã |Ã 3 Pages William Shakespeare is arguably the most well known and successful author is the history of literature. Little is known about ShakespeareÃ¢â¬â¢s childhood and is what questions heÃ¢â¬â¢s existence. Besides the lack of knowledge of his childhood, Shakespeare lived a successful adult life. His plays changed the english language language forever. In all of his success, people still doubt he ever existed. William ShakespeareÃ¢â¬â¢s birth is unknown but church records show that he was baptised on April 26, 1564Read MoreBiography of William Shakespeare Essay example483 Words Ã |Ã 2 PagesBiography of William Shakespeare William Shakespeare was allegedly born in Stratford-upon-Avon, on April 23, 1564. He was baptized in the Holy Trinity Church on April 26, of that same year. His father, John Shakespeare, was a Glover and leather merchant and his mother, Mary Arden, a landed heiress. William was the third of eight children in his family. John Shakespeare had an outstanding run of success as a merchant, and later as anRead MoreBiography of William Shakespeare Essay762 Words Ã |Ã 4 PagesWilliam Shakespeare was born on April 23rd 1564 in Stratford-upon-Avon and died on April 23rd 1616; he was 52 years old when he died and was buried in the Stratford church. His father was John Shakespeare and died in 1601; his mom was Mary Arden and died in 1608. He married to Anne Hathaway the daughter of a farmer. They got three children: Susanna who was born on 1583 and two twins a boy which is Hammet and a girl which is Judith. Susanna was the eldest child and she didnÃ¢â¬â¢t have any education, sheRead MoreBri ef Biography of William Shakespeare1433 Words Ã |Ã 6 PagesThe Life of William Shakespeare William Shakespeare was a very dynamic playwright and writer. He enjoyed history which was shown through his writing. He excelled at writing many kinds of different genres of plays. He especially enjoyed tragedy and history. The reason William Shakespeare remains well known today is because he was a brilliant playwright which was clearly influenced by his childhood and culture. William Shakespeare was born in Stratford, England. On April 23, 1564, he was supposedlyRead MoreA Brief Biography of William Shakespeare617 Words Ã |Ã 3 PagesWilliam Shakespeare, the man of many artistic talents, is still quite a mysterious figure in todayÃ¢â¬â¢s world, mainly because of the lack of records on this man; but also because of his writings. According to what little the Holy Trinity Church had documented on William Shakespeare, the legal and business transactions including some theatrical and Court documents as well as his lifeÃ¢â¬â¢s work, can be used to put the little bits of information given to us to see the basic overview of this manÃ¢â¬â¢s life, useRead MoreA Very Brief Biography of William Shakespeare1609 Words Ã |Ã 6 PagesWilliam Shakespeare William Shakespeare, man with intelligence, creativity, and with great passion for love, was one of the most prestige playwright, poet, and actor from the British Literature. He contributed his whole life writing some of the finest and well known plays and poems that are still highly valued in the present literary world. ShakespeareÃ¢â¬â¢s conventional themes for most of his plays and poems are about universal matters such as love, jealousy, and beauty which were common focus duringRead MoreWilliam Shakespeare s Life Of The English Language1425 Words Ã |Ã 6 Pagesmarket town northwest of London (Biography 2016). William Shakespeare grew up modestly throughout the early years of his life, but the influence that he had in the literary world was anything but. His childhood education and young-adult jobs aided him in creating a name for himself gradually to the theater. With patience and commitment towards his writings, Shakespeare became known as the finest poet of the English lan guage (Lineback 2016). As a child, Shakespeare had two older sisters and three
Friday, May 15, 2020
tion of Cell Organelles Cells are surrounded with a boundary known as the cell surface membrane and as well as holding the cell together, being semi-permeable, it controls the movement of materials across it. Within the cell are a number of structures each which have specific functions. These structures are known as organelles. The cell surface membrane and the membranes of any of the membrane bound organelles described below are made of the same material, a double layer of phospholipid molecules. Within the cell surface membrane, the intracellular space known as the cytoplasm, contains all the organelles and a fluid known as cytosol. Within the cytosol is a network of microtubules and fibres called the cytoskeleton. This cytoskeletonÃ¢â¬â¢s main functions are to give support to the cell helping to maintain its shape and aid the movement of organelles. Most cell organelles and structures are common to both animal and plant cells but there are some differences as outlined in the table below and as seen in fig. 1 and fig. 2. Organelles + structures Present in animal cells Present in plant cells Cell surface membrane Yes Yes Cytoskeleton Yes Yes Nucleus Yes Yes Endoplasmic reticulum Yes Yes Ribosomes Yes Yes Golgi body Yes Yes Mitochondria Yes Yes Lysosomes Yes Rarely Centrioles Yes Not in higher plants Cell wall No Yes Chloroplasts No Yes Vacuole No Yes Animal Cell (Fig.1) PlantShow MoreRelatedThe Structure And Function Of Cell Organelles1763 Words Ã |Ã 8 PagesThe Structure and Function of Cell Organelles Cells are surrounded with a boundary known as the cell surface membrane and as well as holding the cell together, being semi-permeable, it controls the movement of materials across it. Within the cell are a number of structures each which have specific functions. These structures are known as organelles. The cell surface membrane and the membranes of any of the membrane bound organelles described below are made of the same material, a double layer ofRead MoreStructure and Function of Eukaryotic Cell Organelles1800 Words Ã |Ã 8 PagesStructure and Function of Eukaryotic Cell Organelles What are eukaryotic and prokaryotic cells? Organelles in Eukaryotic Cells The Nucleus. Nearly all animal cells have a nucleus, with the only exception being the red blood cell. The nucleus has two major functions, which are housing the DNA and controlling the cellÃ¢â¬â¢s activities. In the centre of the nucleus is the nucleolus. This doesnÃ¢â¬â¢t have a membrane, but holds itself together. In the nucleolus, ribosomes are created through the mixtureRead MoreThe Structure And Function Of Organelles Within A Eukaryotic Cell Essay1376 Words Ã |Ã 6 PagesThe Structure and Function of Organelles within a Eukaryotic Cell The Structure of the Membrane and its Function in Cell Transport The essence of life begins with knowing that all living things are made from cells. Cells and what is contained inside form the basic unit of structure and function in an organism. All cells have the same basic structure, the vital part being organelles. The name organelle comes from the Latin organellea; which means little organ. They can be found in both eukaryoticRead MoreEukaryotic Cells And Its Functions978 Words Ã |Ã 4 PagesÃ¢â¬Å"Eukaryotic cells are complex and include all animal and plant cells. Prokaryotic cells are smaller and simpler, e.g. BacteriaÃ¢â¬ - (AQA 2008) Eukaryotic cells contain membrane-bound organelles, whereas prokaryotic cells do not contain these. Although both of these cells contain DNA, only eukaryotic cells contain a nucleus. The nucleus is the largest organelle, surrounded by a double membrane (nuclear envelope) containing lots of pores. The nuclear membrane protects contents of the nucleus and controlsRead MoreDifference Between Plant And Animal Cells1309 Words Ã |Ã 6 Pages CELL OBSERVATION LAB By Alexandra Escaja-Heiss, Ashley Reeves, Christine Constant Period G1/B3a - Living Systems 10/22/15 Purpose To identify the difference between plant and animal cells, recognize their structures, and to better understand the various functions of those cell organelles. II. Background In 1665 Robert Hooke used an early light microscope to look at a thin slice of cork. Under the microscope the cork looked to have thousands on empty chambers, whichRead MoreTypes Of Cells And Prokaryote And Eukaryote1480 Words Ã |Ã 6 Pagesare two types of cells; Prokaryote and Eukaryote. They have many differences including their structures and functions. The main difference being that a Eukaryote cell has an organised nucleus with a nuclear envelope, whereas a prokaryote cell does not have a nucleus at all. Eukaryotes are much more complex than a prokaryote cell. They have multiple organelles with many different functions. Eukaryotic cells are bigger in size than Prokaryotic cells. Some examples of eukaryotic cells are: animals, plantsRead MoreA Comparison of Eukaryotic and Prokaryotic Cells Essay1304 Words Ã |Ã 6 PagesA Comparison of Eukaryotic and Prokaryotic Cells There are two main types of cells in the world. The simplest cells such as bacteria are known as Prokaryotic cells, and human cells are known as Eukaryotic cells. The main difference between each of these cells is that a eukaryotic cell has a nucleus and a membrane bound section in which the cell holds the main DNA which are building blocks of life. Prokaryotic cells do not have a nucleus. The chromosomes which are found in prokaryotes are usuallyRead MoreCell Lab Report1076 Words Ã |Ã 5 PagesÃ¯ » ¿STRUCTURE AND FUNCTION OF LIVING CELLS Name Answer the following questions as you work your way through the lab material typing in your answers. Then submit your completed lab report through the Ã¢â¬Å"AssignmentÃ¢â¬ feature. This lab report is worth 50 points towards your final lab grade. Also, per the Honor Code, this work must be your own. CELLS Using your Biology Textbook answer the following questions. 1. What types of organisms are Prokaryotes? The Prokaryotes are organisms that areRead MoreMiddle School El Students- Carlos986 Words Ã |Ã 4 Pagesof a cell as a whole and ways parts of cells contribute to the function. Ã¯Æ'Ë SWBAT: Students will be able to identify the different parts of a plant and animal cell Ã¯Æ'Ë SWBAT: Students will be able to describe/ define the function of the parts of a cell Ã¯Æ'Ë SWBAT: Students will create a model of a cell. WV ELP Standards: 1, 2, 5, 7 Language Objectives: Ã¯Æ'Ë SW be able to orally describe the structure and function of a cell to a partner Ã¯Æ'Ë SW define and use scientific terms for cells, organelles, andRead MoreAnimal Cells And Their Functions1044 Words Ã |Ã 5 PagesAnimal cells and their functions Cell Membrane The cell Ã¢â¬Å"surfaceÃ¢â¬ membrane is a semi-permeable membrane whose function is to control the exchange of substances between the cell and its environment. Semi-permeable means that only certain molecules are allowed to be transported in and out of the cell. The membrane is mainly made up of Lipid and protein. On the diagram, the Cell Membrane forms the Ã¢â¬Å"outer shellÃ¢â¬ of the animal cell, and can be seen as the bold line around it. Nucleus The Nucleus has a
Wednesday, May 6, 2020
This paperÃ¢â¬â¢s purpose is to exhibit my understanding of adolescents and how their self-esteem/self-concept, play a role in their educational development. As adolescents progress through middle and high school, forming an opinion of oneself can be a difficult task to accomplish. What self-esteem means is the appraisal of or attitude toward the self (Wagner Ludtke, 2013). Adolescents are trying to identify if they like who they are, if they are confident in this person, a lot of personal turbulence can occur for the individual. Wagner and Ludtke also stated that in early adolescence there is a consistent decrease in self-esteem. One of the many reasons for this is the increasing realistic self-views, and the general focus on negativeÃ¢â¬ ¦show more contentÃ¢â¬ ¦From there, I would have them right down something they struggle with and how they may be able to help themselves get past their own personal struggle (SS1.3). I want my students to know that whatever it is they are goi ng through, they are not alone. There is someone else out there who is struggling with the same issue that they are, and in that they can find a friend to confide in. Not all struggle with self-esteem as much others. Sometimes, the adolescentÃ¢â¬â¢s personality plays a role in whether or not they have low or high self-esteem (Wagner Ludtke, 2013). For example, studies have shown that those individuals who are more mature, which means complete in natural growth or development and emotionally stable, meaning those whose emotions are balanced and under control, seem to show higher self-esteem compared to those who are low in those characteristics (Wagner Ludtke, 2013). I can see where the correlation of this factor and self-esteem play a role. All adolescents are different, therefore they obviously do not have the same type of personalities. My job as their teacher would be to figure out what kind of person they were, and how might I best be able to create activities where they wo uld feel included. It can be stressful for students to be pushed out of their comfort zones in this period of time. So in order for me to create a sense ofShow MoreRelatedStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words Ã |Ã 1573 PagesOrganizational Behavior This page intentionally left blank Organizational Behavior EDITION 15 Stephen P. Robbins Ã¢â¬âSan Diego State University Timothy A. Judge Ã¢â¬âUniversity of Notre Dame i3iEi35Bj! Boston Columbus Indianapolis New York San Francisco Upper Saddle River Amsterdam Cape Town Dubai London Madrid Milan Munich Paris Montreal Toronto Delhi Mexico City Sao Paulo Sydney Hong Kong Seoul Singapore Taipei Tokyo Editorial Director: Sally Yagan Director of Editorial Services:
Tuesday, May 5, 2020
Farewell Speech 1 Good morning, everyone. Today Is a big day, because our dear big brothers and big sisters are leaving. We are very happy but also sad, we are very lucky to meet all of you, we enjoyed studying, playing, talking and singing together. And now you are leaving, we will remember the good time we ever had. Thank you for always helping us, you are going to elementary school, we will miss you very much, please come back to play with us, to your futures. We would like to say big brothers and big sisters, GO! GO! GO! Take care and good luck, thank you. Farewell Speech 2You all have been my friends for 2 years and I must say Im sad to see you go. I hope you find new friends in school, but dont forget about your old friends, K? I love you all and hope that school Is fun for you. Next year, I will come to school, too. Then we can all play and study together again. Farewell Speech 3 Its hard to say goodbye. It is sad that some of us will not be coming back next year. But, very very soon we will all meet up In elementary school. So you guys, keep our seats warm, k? We will miss you. And we wont forget about you. Dont forget us, K? Remember that even IfFarewell Speech 4 Congratulations, friends! You worked every hard for this day. We studied, sang and played together. Good luck In the future. Congratulations and goodbye! Farewell Speech 5 Dear big brothers and big sisters: Congratulations! We are so proud of you that you are going to first grade. Today is your graduation day. Its hard to say goodbye! We wont forget the happy days we learned and played together. Good luck and keep It up for the new school. You have our best wishes. Farewell Speech 6 Hello, everybody: We are here today to say goodbye to those of you that are leaving us.We are sad but know that life will treat you well. We hope you will enjoy your school life. We will miss you and please dont forget us. We hope to see you again. Good luck and best wishes. Farewell Speech 7 Dear everyone: We are sad that some of you are leaving soon. But yet, we are happy to see you turning over a new leaf. We hope you will enjoy your new school and have good teachers taking care of you. We will miss you and please dont forget us. If you have time in the future, please do come and visit us. Good luck and best wishes. Farewell Speech 8 Hello, everyone: Its time to say goodbye again.Congratulations older schoolmates! You are going to start a new life and we know that life will treat you well. We hope that you will enjoy your school life and learn as much as you can from your teachers and classmates. Good luck to you all. Valedictorian Speech 1 Wow! Im so happy today. Today we are graduating! I love you, Mommy and Daddy, you are my best friends. I love you, Teachers and Principal, you are the best in the world. I love you, Classmates. I will miss you. So hurry up and Join us at school, K? Always remember: Believe in yourself! You will make it! Yeah!! Valedictorian Speech 2Wow! It is 2007! Graduation day is finally here! I feel so happy and excited. First let me say Thank you. Without the love from Dad and Mom, my teachers, and the principal, I could never have done it. Thanks my friends! I will never forget you. This year we will start first grade. Im happy and scared, and I know somehow, we will make it. Good luck my friends! Work hard, play hard and love life! Congratulations to us all!! Valedictorian Speech 3 We say good bye to the friends we made. Good luck to you! Side by side, we learned, laughed and grew. We will miss all of our teachers and friends. I know well meet again. Good luck, everyone and goodbye! Valedictorian Speech 4 to say. First, we want to say thank you to our principal and teachers. Thank you, principal, for your guidance. Thank you, teachers, for helping us to learn. Last, we want to say thank you to our schoolmates. Thank you for the good times and the wonderful memories we have shared. Its hard and sad to say goodbye to you all. Farewell, everyone. We will miss you all. Valedictorian Speech 5 Dear principal, teachers, Mom and Dad: Good evening. Today is our graduation day, and we are here to say thank you to all of you.First, wed like to say thank you to our principal and teachers. Thank you for your patience and guidance. You teach us manners and we have learned a lot from you. Thank you for everything you have done. Now, wed like to say thank you to our moms and dads. Thank you for taking care of us every day. Last, wed like to say thank you to our moms and dads. Thank you for taking care of us every day. Last, wed like to say thank you to our friends. Thank you for the good times we spent together. We wont forget any of you. Now lets say goodbye to each other. Farewell, everyone. Goodbye. Valedictorian Speech 6Good morning, dear Principal, teachers and everybody here. Today is our graduation day, and we have a lot to say. First, we would like to say thank you to our Principal and teachers. Thank you for teaching us and taking good care of us. We also would like to say thank you to our parents. Thank you for sending us to this warm and lovely place. Last, we would like to say thank you to our schoolmates. Thank you for the good times and the wonderful memories we have shared. Goodbye, Principal. Goodbye, teachers. Goodbye, my dear younger schoolmates. We know we will always love each other, through the good and the bad.We promise we will remember you forever and we give you our best wishes. And now let us say Goodbye to our Kindergarten. Goodbye. Goodbye. Valedictorian Speech 7 Dear Principal and teachers, dear Mom and Dad, we are here to thank you all for taking care of us so well. Thank you, Principal; thank you, teachers. Thank you for your patience and guidance. Thank you, Mom; thank you, Dad. Thank you for bringing me here day after day. Today is our graduation day, so lets celebrate and shout hurray. Please do not cry, or wipe our tears, because we will always remember the good time we had here.